Saccharomyces cerevisiae

Yeast Protein Function Assignment

Enter a yeast ORF name (for example, YOR128C):

or choose from the complete list of yeast ORFS.
Approximately 24,000 unique links have been established among 2356 of the 6217 proteins of Saccharomyces cerevisiae by methods described in Assigning Protein Functions by Comparative Genome Analysis: Protein Phylogenetic Profiles (Proc. Natl. Acad. Sci 96:4285-4288 (1999), link to PNAS abstract or Medline abstract) and in Detecting Protein Function and Protein-Protein Interactions from Genome Sequences ( Science 285:751-753 (1999), link to Science abstract or Medline abstract). Approximately 2500 additional links are derived from known experimental interactions in the DIP database and MIPS database, from yeast proteins whose E. coli homologs catalyze sequential metabolic reactions (as defined in the EcoCyc database), and from yeast proteins whose mRNAs show correlated expression patterns using publicly available gene chip data from the Stanford Genomic group and Pat Brown's Lab. Lastly, we predict a protein's function from the function of proteins that it is linked to using the hierarchal annotations of the MIPS yeast database. Explanation of the prediction methods, error rates, etc. appears in A Combined Algorithm for Genome-Wide Prediction of Protein Function ( Nature 402:83-86 (1999), link to Nature abstract).
Alternatively, look for links in our lower confidence, but larger, set of ~ 94,000 links, covering 4701 of the 6217 yeast proteins.
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Edward Marcotte

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Last modified: Fri Nov 11 11:05:20 MET 1999

Copyright © 1999, Edward Marcotte and David Eisenberg. The yeast protein function assignment data and server is the property of the Regents of the University of California, and cannot be used for commercial purposes without written permission of David Eisenberg and the Regents of UC. It is forbidden to redistribute, derivatize, or encapsulate the yeast protein function server or data in another database without permission. Sale of information derived from it, whether directly or in revised form, is forbidden except by permission of UCLA and David Eisenberg. All copies or mirrors of the yeast protein function server must carry this notice.